What causes platelets to clump

what causes platelets to clump

Platelet Clumping

Platelets are tiny fragments of cells that can be found throughout every person’s bloodstream. The purpose for these fragments is to address and seal any breaks in blood vessels, such as tears, scrapes, and cuts. This achieved through the clumping of platelets over the . Platelet clumping occurs when the blood platelets responsible for coagulation stick to one another to form clusters. The presence of platelet clumping has no clinical consequences other than preventing instruments from properly counting blood platelets. Platelet clumps tend to form in samples collected with difficulty and in a small number of individuals (about 1/) whose platelets react with the EDTA .

At Healthfully, we strive to deliver objective content that is accurate and up-to-date. Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care what causes platelets to clump. Please check with the appropriate physician regarding health questions and concerns.

Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. Each year, hundreds of thousands of American develop new blood clots that often lead to disability and death, according to the U. Surgeon General. For 4, years, folk medicine practitioners have been using extracts from the juice of red pomegranate fruits to treat a variety of health conditions including blood vessel disorders.

Modern researchers investigating those effects are finding that pomegranate juice may help promote cardiovascular health. Blood clots can form in your arteries or in a vein, known as deep vein thrombosis. Clots are formed by platelet cells that form over skin wounds and around injured blood vessels to help your body heal. After the clots have done their job, your body dissolves them.

When clots form in the arteries that supply blood to your heart, they can cause heart attacks. Free radicals are molecules in your body that attack and damage DNA and cells, leading to disease. Free radicals can oxidize unhealthy LDL cholesterol, converting it into plaques that clog your arteries Antioxidants are compounds found in many plant sources, including pomegranates and pomegranate juice, what to do when your knee gives out prevent the conversion of cholesterol into plaques.

The type of antioxidant found in pomegranates and other what causes platelets to clump is called a polyphenol, with pomegranates having higher levels of polyphenols than red wine, blueberry juice and green tea. This condition is caused in part by the accumulation of LDL and fats and increases the risk of blood clots forming in those arteries. It reported that pomegranate polyphenols are effectively able to prevent atherosclerotic plaques and LDL oxidation.

Pomegranate juice also protected against the proliferation of thromboxane, a substance made what are the different points of view in a story platelets that causes blood clotting and constriction of blood vessels.

Pomegranate juice may interact with anticoagulant drugs taken to prevent blood clots, increasing their effects. There are a few reports of people with plant allergies who experienced an allergic reaction to pomegranate. Bonnie Singleton has been writing professionally since She has written for various newspapers and magazines including "The Washington Times" and "Woman's World. Singleton holds a master's degree in musicology from Florida State University and is a member of the American Independent Writers.

Monitor the health of your community here. More Articles. Mattiello, et al. Aviram; The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Weight Management. Written by Bonnie Singleton.

Aviram; Pomegranate. Professional Monograph. Natural Medicine Database. Therapeutic Resource Center. Punica granatum Pomegranate activity in health promotion and cancer prevention.

Oncol Rev. Published Jan The antiplaque efficacy of pomegranate mouthrinse. Quintessence International. Danesi F, Ferguson LR. Published Aug Effects of pomegranate juice on human cytochrome p 3A CYP3A and carbamazepine pharmacokinetics in rats. Drug Metabolism and Disposition. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. Journal of Ethnopharmacology. Inhibitory effects of fruit juices on CYP3A activity. Sahebkar, A.

Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research,— Rhabdomyolysis associated with pomegranate juice consumption.

American Journal of Cardiology. The effect of pomegranate what causes platelets to clump juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Dawley rats [published correction appears in BMC Complement Altern Med. Published Mar Vasculoprotective Effects of Pomegranate Punica granatum L.

Front Pharmacol. Published May Potent health effects of pomegranate. Adv Biomed Res.

Platelet clump

Health related conditions can cause abnormal platelet clumping. Cholesterol in the blood can eventually collect along the smooth surface of vessel walls. This provides a surface on which platelets can clump together. Tissue damage results when blood supply is stopped by a plugged blood vessel. Excessive platelet production is another cause of abnormal clumping. Dec 01,  · Causes of platelet clumping include platelet activation (due to traumatic venipuncture) and EDTA-dependent antibodies that react with platelet glycoprotein IIb/IIIa. In the latter case, the clumping can be corrected by using blood collection tubes containing an alternative anticoagulant, such as sodium citrate.

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